Take advantage of this helpful information and resource center to strengthen your business.


Setting up a Business in Otay Mesa (City of San Diego)

Otay Mesa Chamber of Commerce

Here are the ten key steps for opening a new business in the City of San Diego portion of Otay Mesa

Setting up a Business in East Otay Mesa

Otay Mesa Chamber of Commerce

Search for Unincorporated Area – San Diego County

The CA International Trade Center

Otay Mesa Chamber of Commerce

The CA International Trade Center helps California small and medium businesses leverage digital tools to go global.

Small Business Self employed Tax Center

Small Business Self Employed Tax Center on This Tax Center contains links to valuable information for the small business owner such as:

  •  Starting and Operating a Business,
  •  Independent Contractor (Self-Employed) or Employee?,
  •  IRS Video Portal (video, webinars and audio presentations for small businesses, individuals and tax pros)
City of San Diego & State of California Business Incentives

Permit Entitlement Assistance
The City of San Diego has dedicated staff available to assist businesses and developers in securing required City entitlements, including permits for right-of-way, grading, new construction, and tenant improvements. In this support role, Economic Development staff are directly engaged with the City’s Development Services, Planning, and Public Utilities Departments to assist in expediting construction entitlements, identifying fees, and issues mediation.

Border Wait Times and Border Crossing Statistics

 The Otay Mesa Chamber understands the importance of reducing wait times at our land ports of entry and is constantly working with Customs and Border Protection and other stakeholders to address this important goal.




$10,000 Grant Opportunity for Small Businesses

Verizon has a small business portal with free courses and an opportunity to apply for a $10,000 grant. To be eligible to apply for the grant, you only have to complete two 40 minute courses, which by the way are quite useful for your business. You can use the $10,000 to support your operations or expand and no need to pay it back. More info on the grant can be found In the PDF. 

The first step is to register your business in the Verizon business portal and that only takes 2 minutes. Here is the link.

You must register to the portal and apply for the grant before June 30th.

Warehouse Ordinance Comment Letter
Free Business Services (SCORE)

SCORE provides free business start up-advice, as well as access to specialized workshops.

On the Job Training Program

Take advantage of Substantial Financial Benefits with reimbursement of 50% of the wages earned by eligible new workers.  It’s quick and simple – all paperwork is managed by the South County Career Center.  Cash back for every new employee in the program you train and hire. For additional details, download the OJT flyer and contact one of our Business Services staff. On the Job Training Flyer

Free Business Services (South County Career Center)

The South County Career Center offers a number of free Business Services, which include:

  • Recruitment and hiring assistance
  • Job descriptions and Job postings
  • Marketing and distribution of openings
  • Job Fairs
  • Recruitment events
  • Space available for one on one interviews
  • Labor Market Information
  • Sector Strategy Information
  • Up to date regional information on hiring trends
  • Customized Training
  • Tax Credits
  • Work Opportunity Tax Credit (WOTC) (Federal)